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Phenotypes Associated with This Genotype
Genotype
MGI:5911576
Allelic
Composition
Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• lineage skewing is seen following prolonged doxycycline exposure (30 days)
• in the splenic parenchyma
• decrease in the Ter119+ cell population
• hypercellular bone marrow with erythroid and megakaryocytic hypoplasia and marked myeloid hyperplasia
• in the GFP+ cells in the bone marrow
• in peripheral blood of aged mice
• decrease in the proportion of B cell population (B220+)
• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells
• increased amount of early erythroid (CD71+/Ter119+) cells in the spleen
• aged mice show marked expansion of myeloid elements (granulocytic > monocytic) in the peripheral blood
• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability
• decrease in the number of GFP+ cells in the long-term (CD150+) and short-term (CD150-/CD48-) subsets
• compensated for with an increase in the CD150+/CD48+ multipotent progenitor subset

immune system
• aged mice show marked expansion of myeloid elements (granulocytic > monocytic) in the peripheral blood
• in peripheral blood of aged mice
• decrease in the proportion of B cell population (B220+)

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myeloproliferative neoplasm DOID:2226 J:229031


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory