hematopoietic system
• lineage skewing is seen following prolonged doxycycline exposure (30 days)
|
• in the splenic parenchyma
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• decrease in the Ter119+ cell population
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• hypercellular bone marrow with erythroid and megakaryocytic hypoplasia and marked myeloid hyperplasia
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• in the GFP+ cells in the bone marrow
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• in peripheral blood of aged mice
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• decrease in the proportion of B cell population (B220+)
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• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells
• increased amount of early erythroid (CD71+/Ter119+) cells in the spleen
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• aged mice show marked expansion of myeloid elements (granulocytic > monocytic) in the peripheral blood
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• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability
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• decrease in the number of GFP+ cells in the long-term (CD150+) and short-term (CD150-/CD48-) subsets
• compensated for with an increase in the CD150+/CD48+ multipotent progenitor subset
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• in the spleen
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• in aged mice
|
immune system
• aged mice show marked expansion of myeloid elements (granulocytic > monocytic) in the peripheral blood
|
• in peripheral blood of aged mice
|
• decrease in the proportion of B cell population (B220+)
|
• in aged mice
|
growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
myeloproliferative neoplasm | DOID:2226 | J:229031 |