Analysis Tools
muscle
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• disorganized tongue muscle fibers at E14
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mortality/aging
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• die around the time of birth
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cardiovascular system
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• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
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• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
• at E11 the outflow tract has a lower density of cardiac neural crest cells and these cells are disorganized
• however, septation occurs normally
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• in some embryos
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• malformed outflow tract valves in 90% of mice at E12
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nervous system
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• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
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• smaller and misshapen
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• less affected compared to germline null mice
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vision/eye
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• at E17
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• fail to grow and close over the eye bulb at E17
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skeleton
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• boundary of ossification is abnormal
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• severely malformed
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• poorly developed
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• severely malformed palatal cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
• otic capsule cartilage is absent at E16 in 33% of mice and reduced in 66% of mice
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hearing/vestibular/ear
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• cartilage is absent at E16 in 33% of mice and reduced in 66% of mice
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craniofacial
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• boundary of ossification is abnormal
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• severely malformed
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• poorly developed
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• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
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• disorganized tongue muscle fibers at E14
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• small tongue at E14
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digestive/alimentary system
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• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
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• disorganized tongue muscle fibers at E14
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• small tongue at E14
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growth/size/body
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• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
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• disorganized tongue muscle fibers at E14
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• small tongue at E14
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embryo
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• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
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