Analysis Tools
cardiovascular system
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• left ventricle wall thickness at optimal volume is increased
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• deposits of collagen in the right ventricle, left ventricle, and interventricular septum indicating cardiac fibrosis
• larger deposits of collagen are seen in calcified regions
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• heart exhibits calcifications in the cardiac wall in most mice
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• developed pressure, rate of pressure increase, and developed wall stress are reduced, suggesting that active force generation of the contractile apparatus is reduced
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• heart exhibits lower developed pressure
• lower developed pressure is associated with a lower rate of pressure change (dP/dt) during the rising and falling phases of contraction
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• heart exhibits increased diastolic pressures at all filling volumes
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• active stress generated at maximal calcium concentration is lower in isolated skinned trabecular muscle
• the active force during the contraction of maximal calcium concentration at the end of the determination of calcium-sensitivity is slightly lower in isolated skinned trabecular muscle
• however, the calcium-sensitivity of force is unchanged
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growth/size/body
muscle
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• developed pressure, rate of pressure increase, and developed wall stress are reduced, suggesting that active force generation of the contractile apparatus is reduced
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cardiomyopathy | DOID:0050700 | J:130557 | ||
