Phenotypes Associated with This Genotype

Genotype
MGI:5912151

cn3

• Allelic Composition: Mcu^tm1.1Jmol/Mcu^tm1.1Jmol; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

abnormal mitochondrial physiology ( J:235756 )

• cardiomyocytes, endothelial cells and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells

• however, mitochondrial membrane potential is normal

respiratory system

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )