Phenotypes Associated with This Genotype

Genotype
MGI:5912341

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-Kras2)12Hev/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:73468 )

• in doxycycline-treated mice

• however, tumors regress after doxycycline withdrawal due to apoptosis

increased lung adenoma incidence ( J:73468 )

• multiple large, solid-type adenomas in doxycycline-treated mice

increased lung adenocarcinoma incidence ( J:73468 )

• in doxycycline-treated mice

respiratory system

increased lung tumor incidence ( J:73468 )

• in doxycycline-treated mice

• however, tumors regress after doxycycline withdrawal due to apoptosis

increased lung adenoma incidence ( J:73468 )

• multiple large, solid-type adenomas in doxycycline-treated mice

increased lung adenocarcinoma incidence ( J:73468 )

• in doxycycline-treated mice

abnormal respiratory system physiology ( J:73468 )

• proliferative alveolar lesions and focal hyperplasia of type II pneumocytes in doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung adenocarcinoma		DOID:3910		J:73468