Phenotypes Associated with This Genotype

Genotype
MGI:5912375

• Allelic Composition: Kit^W/Kit^W
• Genetic Background: B6.Cg-Kit^W/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:243758 )

• weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings

hematopoietic system

macrocytic anemia ( J:243758 )

• identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is greatest in W/W homozygotes compared with homozygotes for the viable dominant spotting allele or compound heterozgyotes

mortality/aging

abnormal survival ( J:243758 )

• heterozygous intercrosses produce only 14.5% homozygotes instead of the 25% expected, one sixth of which are born dead or die perinatally and nearly all the remainder die by 3 days of age, without postnatal growth

perinatal lethality, incomplete penetrance ( J:243758 )

prenatal lethality ( J:243758 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
macrocytic anemia		DOID:2361		J:243758