Phenotypes Associated with This Genotype

Genotype
MGI:5912489

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-ERBB2*)5BKkw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:143874 )

• caused by asphyxiation due to intrabronchial carcinoma in doxycycline-treated mice

• all doxycycline-treated mice die by 30 weeks

neoplasm

increased lung tumor incidence ( J:143874 )

• in doxycycline-treated mice after 2 to 3 weeks with increasing tumor volume over a 30 week period

• tumors in doxycycline-treated mice develop from bronchiolar epithelium

• however, withdrawal of doxycycline leads to tumor regression

increased lung carcinoma incidence ( J:143874 )

• intrabronchal carcinomas after 15 to 18 weeks leading to asphyxiation in doxycycline-treated mice

increased lung non-small cell carcinoma incidence ( J:143874 )

• doxycycline-treated mice develop adenosquamous carcinomas

respiratory system

increased lung tumor incidence ( J:143874 )

• in doxycycline-treated mice after 2 to 3 weeks with increasing tumor volume over a 30 week period

• tumors in doxycycline-treated mice develop from bronchiolar epithelium

• however, withdrawal of doxycycline leads to tumor regression

increased lung carcinoma incidence ( J:143874 )

• intrabronchal carcinomas after 15 to 18 weeks leading to asphyxiation in doxycycline-treated mice

increased lung non-small cell carcinoma incidence ( J:143874 )

• doxycycline-treated mice develop adenosquamous carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adenosquamous lung carcinoma		DOID:4829		J:143874