Analysis Tools
mortality/aging
|
• average lifespan is 109 days post tamoxifen injection
|
nervous system
microgliosis
(
J:176888
)
|
• widespread microgliosis in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
|
• accumulation of unesterified cholesterol in cerebellar lobule X in tamoxifen-treated mice at 18 weeks of age
|
|
• progressive anterior-to-posterior Purkinje cell loss in tamoxifen-treated mice
• cells in anterior lobules degenerate early and those in posterior lobules are more resistant to degeneration
|
astrocytosis
(
J:176888
)
|
• widespread astrocytosis in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
|
• tamoxifen-treated mice exhibit swollen axons in the cortex at 22 weeks of age
|
|
• widespread axonal spheroids in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
|
• tamoxifen-treated mice exhibit demyelination in the corpus callosum at 22 weeks of age
• widespread secondary demyelination in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
behavior/neurological
|
• mice injected with tamoxifen at 6 weeks of age exhibit impaired balance beam performance by 12 weeks which progresses with age
|
growth/size/body
weight loss
(
J:176888
)
|
• mice injected with tamoxifen at 6 weeks of age start to lose weight around 16 weeks of age
|
hematopoietic system
microgliosis
(
J:176888
)
|
• widespread microgliosis in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
homeostasis/metabolism
|
• accumulation of unesterified cholesterol in cerebellar lobule X in tamoxifen-treated mice at 18 weeks of age
|
immune system
microgliosis
(
J:176888
)
|
• widespread microgliosis in the cerebellum of tamoxifen-treated mice at 18 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Niemann-Pick disease | DOID:14504 | J:176888 | ||
