mortality/aging
|
• decrease in survival of male mice is seen from 7 months of age
|
neoplasm
• 68% of mice exhibit parathyroid tumors between 9 and 18 months of age
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• however, ossifying fibromas of the jaw, and tumors of the kidneys, thyroid, pancreas or testis are not seen
|
• 25% of parathyroid tumors are adenomas and 75% are atypical parathyroid adenomas
|
|
• 33% of females aged over 18 months of age exhibit uterine tumors
• uterine tumors include adenofibroma and adenomyoma
|
craniofacial
• jaw bones show 2-fold increase in proliferation rates
|
endocrine/exocrine glands
• 68% of mice exhibit parathyroid tumors between 9 and 18 months of age
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• however, ossifying fibromas of the jaw, and tumors of the kidneys, thyroid, pancreas or testis are not seen
|
• 25% of parathyroid tumors are adenomas and 75% are atypical parathyroid adenomas
|
• mice over 17 months of age show features of primary hyperparathyroidism
|
homeostasis/metabolism
• mice with parathyroid tumors exhibit increased mean serum parathyroid hormone concentration
|
• mice with parathyroid tumors exhibit increased mean serum calcium concentrations
• however, levels of serum phosphate, creatinine, and albumin are normal
|
reproductive system
uterus cyst
(
J:243366
)
|
• uteri of females aged over 18 months has large cysts within the endometrium
|
|
• 33% of females aged over 18 months of age exhibit uterine tumors
• uterine tumors include adenofibroma and adenomyoma
|
|
• endometrial hyperplasia with areas of squamous metaplasia
|
|
• myometria have a 2-fold increase in proliferation rates
|
skeleton
• jaw bones show 2-fold increase in proliferation rates
|
growth/size/body
uterus cyst
(
J:243366
)
|
• uteri of females aged over 18 months has large cysts within the endometrium
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hyperparathyroidism | DOID:13543 |
OMIM:145000 OMIM:145001 OMIM:610071 |
J:243366 |