Phenotypes Associated with This Genotype

Genotype
MGI:6095193

• Allelic Composition: Tg(Prnp-TARDBP*Q331K)103Dwc/0
• Genetic Background: B6.Cg-Tg(Prnp-TARDBP*Q331K)103Dwc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oxidative stress ( J:242322 )

• induction of glutathione levels in response to sodium arsenite is impaired in primary astrocyte cultures and mice show an increase in transcripts of the antioxidant genes Hmox1 and Nqo1in the spinal cord, indicating elevated oxidative stress and impaired antioxidant response

nervous system

abnormal brain morphology ( J:242322 )

• loss of insoluble heterogeneous nuclear ribonucleoprotein K in the brain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 10		DOID:0060201	OMIM:612069	J:242322