Phenotypes Associated with This Genotype

Genotype
MGI:6098753

• Allelic Composition: Mecp2^tm1.1Bird/Mecp2⁺
• Genetic Background: B6.129P2(C)-Mecp2^tm1.1Bird/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart rate ( J:241788 )

♀ • 9 month old females exhibit erratic heart rate patterns, with sudden pauses in the regular rhythm of the heart rate and bradycardic events

increased heart rate variability ( J:241788 )

♀

decreased heart rate ( J:241788 )

♀ • mice have a higher incidence of sudden bradycardic events

♀ • 28 month old females develop a decreased heart rate which is not seen in 9 month old mice

irregular heartbeat ( J:241788 )

♀ • 9 month old females present with a variety of spontaneous cardiac arrhythmias ranging from sinus pauses and atrioventricular block to aberrant ventricular contractions

♀ • non-sustained ventricular arrhythmias are seen in 9 month old females

ventricular premature beat ( J:241788 )

♀ • 9 month old males are susceptible to premature ventricular contractions

atrioventricular block ( J:241788 )

♀ • atrioventricular block is seen at a higher rate in 9 month old females

homeostasis/metabolism

decreased body temperature ( J:241788 )

♀ • 28 month old females develop decreased temperature which is not seen in 9 month old mice

behavior/neurological

behavior/neurological phenotype ( J:241788 )

♀N • mice exhibit normal activity levels during both the light and dark cycles at 9 and 28 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788