Analysis Tools
mortality/aging
 |
• 67% of mice die early with a median life span of 16 months
|
cardiovascular system
|
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• irregular heart rhythm and sudden drops in heart rate
|
|
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• increase in heart rate variability during both the light and dark cycles
|
|
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• heart rate during the dark cycle is decreased but is not different during the light cycle
|
|
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• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
|
|
|
• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
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|
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• mice are highly susceptible to inducible arrhythmias
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homeostasis/metabolism
|
|
• mice are highly susceptible to inducible arrhythmias
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|
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• mice exhibit decreased temperature during the dark cycle but not the light cycle
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behavior/neurological
|
N |
• mice show no differences in activity during the light or dark cycle
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respiratory system
|
N |
• mice do not exhibit increased basal apneas or abnormal hypoxic response
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:241788 | |
