Phenotypes Associated with This Genotype

Genotype
MGI:6099056

• Allelic Composition: Tg(Th-SNCA)5Eric/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:96494 )

♂ • locomotor activity is 78% of littermate controls by 21-23 months of age

♂ • treatment with apomorphine has little impact on locomotor activity in mutants compared to a decrease in control littermates

homeostasis/metabolism

decreased dopamine level ( J:96494 )

♂ • mice exposed to combined pesticides show a slight decrease (18%) in dopamine levels compared to littermate controls (3%)

increased physiological sensitivity to xenobiotic ( J:96494 )

♂ • mice exposed to combined pesticides show a slight decrease (18%) in dopamine levels compared to littermate controls (3%)

nervous system

increased dopaminergic neuron number ( J:96494 )

♂ • mice show a modest but significant increase of about 10-15% in numbers of TH+ neurons in the substantia nigra pars compacta at 2.5 months of age

loss of dopaminergic neurons ( J:96494 )

♂ • mice show a significant loss of TH+ neurons across time in the substantia nigra pars compacta, with an approximate 3% loss at 8.5 months and approximate 13% loss at 19 months of age

♂ • however, inclusions are not seen in the substantia nigra pars compacta

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:96494