Phenotypes Associated with This Genotype

Genotype
MGI:6101205

• Allelic Composition: Ext1^tm1Yama/Ext1^tm1Yama; Acan^{tm1(cre/ERT2)Crm}/Acan⁺
• Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased osteochondroma incidence ( J:242977 )

• mice injected with tamoxifen at P28 or P35 form large osteochondromas along synchondroses in the cranial base and along growth plates of long bones by 6-8 weeks after injection

• systemic treatment of tamoxifen-injected with mice a BMP signaling antagonist, LDN-193189 reduces osteochondroma development and growth

skeleton

increased osteochondroma incidence ( J:242977 )

• mice injected with tamoxifen at P28 or P35 form large osteochondromas along synchondroses in the cranial base and along growth plates of long bones by 6-8 weeks after injection

• systemic treatment of tamoxifen-injected with mice a BMP signaling antagonist, LDN-193189 reduces osteochondroma development and growth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary multiple exostoses		DOID:206	OMIM:133700 OMIM:133701 OMIM:600209	J:242977