Phenotypes Associated with This Genotype

Genotype
MGI:6102909

• Allelic Composition: Fbxo11^Jf/Fbxo11⁺
• Genetic Background: involves: BALB/cAnNCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250208 )

N • mice exhibit normal inner ear morphology

middle ear effusion ( J:250208 )

middle ear polyps ( J:250208 )

• edematous polyps projecting into the middle ear cavity

impaired hearing ( J:250208 )

• poor performance to the click-box

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological

abnormal pinna reflex ( J:250208 )

• poor performance to the click-box

homeostasis/metabolism

middle ear effusion ( J:250208 )

immune system

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:250208