Phenotypes Associated with This Genotype

Genotype
MGI:6107638

hm1

• Allelic Composition: Mmachc^{Gt(AZ0348)Wtsi}/Mmachc^{Gt(AZ0348)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
• Cell Lines: AZ0348

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased trophectoderm cell proliferation ( J:212387 )

• compromised generation of giant cells in blastocysts developed from E3.5 conceptuses in vitro

embryo

decreased trophectoderm cell proliferation ( J:212387 )

• compromised generation of giant cells in blastocysts developed from E3.5 conceptuses in vitro

abnormal blastocyst formation ( J:212387 )

• delayed blastocyst formation of E3.5 conceptuses in vitro

failure of blastocyst to hatch from the zona pellucida ( J:212387 )

• blastocysts developed from E3.5 conceptuses in vitro

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:212387 )

• expected Mendelian ratio with heterozygous crosses at E3.5

• no homozygous KOs post-implantation

reproductive system

impaired embryo implantation ( J:212387 )

• no homozygous KOs post-implantation