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Phenotypes Associated with This Genotype
Genotype
MGI:6110851
hm1
Allelic
Composition		 Slc15a3tm1a(KOMP)Wtsi/Slc15a3tm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Slc15a3tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc15a3tm1a(KOMP)Wtsi mutation (3 available); any Slc15a3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal myeloid dendritic cell morphology ( J:210445 )
• after LPS (lipopolysaccharide) treatment, fewer than 30% of bone marrow-derived dendritic cells (BMDCs) show tubular endo-lysosomes, vs 80% WT
• reduced expression of Il1b and Il6

immune system
abnormal myeloid dendritic cell morphology ( J:210445 )
• after LPS (lipopolysaccharide) treatment, fewer than 30% of bone marrow-derived dendritic cells (BMDCs) show tubular endo-lysosomes, vs 80% WT
• reduced expression of Il1b and Il6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory