Phenotypes Associated with This Genotype

Genotype
MGI:6114163

cx24

• Allelic Composition: Cav3^tm1Ncnp/Cav3⁺; Dmd^mdx/Dmd^mdx
• Genetic Background: involves: 129S4/SvJae * C57BL/10 * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle development ( J:150127 )

♀ • loss of hind limb Pax7+ myoblasts at E17.5

abnormal muscle fiber morphology ( J:150127 )

♀ • myotubes are hypotrophic in E13.5-E17.5 muscles

♀ • total myotube number per muscle is reduced

♀ • high number of centrally located myonuclei at E17.5

♀ • misalignment of myotubules in muscle at E13.5-E17.5

centrally nucleated skeletal muscle fibers ( J:150127 )

♀ • high number of centrally located myonuclei at E17.5

abnormal intercostal muscle morphology ( J:150127 )

♀ • extensive loss of intercostal muscle fibers at E17.5 with reduced intercostal muscle fiber density

♀ • 71.2% depletion of intercostal myotubes by E17.5