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Phenotypes Associated with This Genotype
Genotype
MGI:6115021
Allelic
Composition
Otud7aem1Cpsc/Otud7aem1Cpsc
Genetic
Background
C57BL/6J-Otud7aem1Cpsc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otud7aem1Cpsc mutation (1 available); any Otud7a mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• reduced acoustic startle response
• impaired performance on rotarod
• impaired ultrasonic vocalization
• delay in development of negative geotaxis reflex
• delay in development of cliff aversion
• repetitive-spike events and some seizure-like events associated with behavioral arrest

craniofacial
• delayed incisor growth

growth/size/body
• delayed incisor growth
• 30% weight reduction

nervous system
• repetitive-spike events and some seizure-like events associated with behavioral arrest
• reduced in the frontal cortex
• females exhibit reduced prepulse inhibition

skeleton
• delayed incisor growth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chromosome 15q13.3 microdeletion syndrome DOID:0060394 OMIM:612001
J:259730


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory