behavior/neurological
• reduced acoustic startle response
|
• impaired performance on rotarod
|
• impaired ultrasonic vocalization
|
• delay in development of negative geotaxis reflex
• delay in development of cliff aversion
|
• repetitive-spike events and some seizure-like events associated with behavioral arrest
|
craniofacial
• delayed incisor growth
|
growth/size/body
• delayed incisor growth
|
• 30% weight reduction
|
nervous system
• repetitive-spike events and some seizure-like events associated with behavioral arrest
|
• reduced in the frontal cortex
|
• females exhibit reduced prepulse inhibition
|
skeleton
• delayed incisor growth
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
chromosome 15q13.3 microdeletion syndrome | DOID:0060394 |
OMIM:612001 |
J:259730 |