Phenotypes Associated with This Genotype

Genotype
MGI:6115249

• Allelic Composition: Rp2^{Gt(EUCJ0183f04)Hmgu}/Y
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased susceptibility to age-related retinal degeneration ( J:219642 )

♂ • slowly progressive retinal degeneration, showing progressive rod-cone dystrophy

abnormal electroretinogram waveform feature ( J:219642 )

♂ • both rod and cone photoreceptors of mice at 6 months of age suffer severe vision loss as indicated by ERG recordings

decreased a-wave amplitude ( J:219642 )

♂ • scotopic a-wave amplitude is reduced as early as 1 month of age

decreased b-wave amplitude ( J:219642 )

♂ • photopic b-wave amplitude is reduced as early as 1 month of age

abnormal vision ( J:219642 )

♂ • vision loss is seen in 6 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 2		DOID:0110415	OMIM:312600	J:219642