Phenotypes Associated with This Genotype

Genotype
MGI:6115250

• Allelic Composition: Rp2^{Gt(EUCJ0183f04)Hmgu}/Rp2^{Gt(EUCJ0183f04)Hmgu}
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased susceptibility to age-related retinal degeneration ( J:219642 )

♀ • slowly progressive retinal degeneration, showing progressive rod-cone dystrophy

abnormal eye physiology ( J:219642 )

♀ • trafficking of PDE6 and GRK1 to cone outer segments is defective

♀ • however, localization of transmembrane proteins ML-opsin, S-opsin, rhodopsin, and GC1 in the outer segments is normal

abnormal electroretinogram waveform feature ( J:219642 )

♀ • both rod and cone photoreceptors of mice at 6 months of age suffer severe vision loss as indicated by ERG recordings

decreased a-wave amplitude ( J:219642 )

♀ • scotopic a-wave amplitude is reduced as early as 1 month of age

abnormal b-wave amplitude ( J:219642 )

♀ • photoptic b-wave amplitudes show a delay in return to the baseline

decreased b-wave amplitude ( J:219642 )

♀ • photopic b-wave amplitude is reduced as early as 1 month of age

abnormal vision ( J:219642 )

♀ • vision loss is seen in 6 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 2		DOID:0110415	OMIM:312600	J:219642