Phenotypes Associated with This Genotype

Genotype
MGI:6117828

hm1

• Allelic Composition: Foxn3^Gt(XE749)Byg/Foxn3^Gt(XE749)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:164801 )

• at E13.5

abnormal neurocranium morphology ( J:164801 )

• at P8 and P11

abnormal basisphenoid bone morphology ( J:164801 )

• at P2

abnormal frontal bone morphology ( J:164801 )

• at P8 and P11

abnormal occipital bone morphology ( J:164801 )

• at P8 and P11

abnormal basioccipital bone morphology ( J:164801 )

• at P2

abnormal parietal bone morphology ( J:164801 )

• at P8 and P11

abnormal temporal bone tympanic part morphology ( J:164801 )

• at P2

thin neurocranium ( J:164801 )

• at P8

long lower incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

long upper incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

malocclusion ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

mandible hypoplasia ( J:164801 )

• at P2

abnormal palate bone morphology ( J:164801 )

• at P2

abnormal palatal shelf fusion at midline ( J:164801 )

• at P2

skeleton

abnormal craniofacial bone morphology ( J:164801 )

• at E13.5

abnormal neurocranium morphology ( J:164801 )

• at P8 and P11

abnormal basisphenoid bone morphology ( J:164801 )

• at P2

abnormal frontal bone morphology ( J:164801 )

• at P8 and P11

abnormal occipital bone morphology ( J:164801 )

• at P8 and P11

abnormal basioccipital bone morphology ( J:164801 )

• at P2

abnormal parietal bone morphology ( J:164801 )

• at P8 and P11

abnormal temporal bone tympanic part morphology ( J:164801 )

• at P2

thin neurocranium ( J:164801 )

• at P8

long lower incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

long upper incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

malocclusion ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

mandible hypoplasia ( J:164801 )

• at P2

abnormal palate bone morphology ( J:164801 )

• at P2

scoliosis ( J:164801 )

• at age 3 months

delayed cranial suture closure ( J:164801 )

• at P8 and P11

growth/size/body

long lower incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

long upper incisors ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

malocclusion ( J:164801 )

• in around 18% of surviving mice at age 6 weeks

abnormal palate bone morphology ( J:164801 )

• at P2

abnormal palatal shelf fusion at midline ( J:164801 )

• at P2

microcephaly ( J:164801 )

decreased body size ( J:164801 )

• severe reduction at E13.5

decreased body weight ( J:164801 )

• severe runting at E13.5

postnatal growth retardation ( J:164801 )

• at age 3 months

mortality/aging

postnatal lethality, incomplete penetrance ( J:164801 )

• reduced Mendelian ratio suggests 30% survival rate on postnatal day 21 (P21)

embryonic lethality, incomplete penetrance ( J:164801 )

• reduced Mendelian ratio suggests 62% survival rate on neonatal day 1 (P1)

nervous system

abnormal brain morphology ( J:164801 )

• at E13.5

digestive/alimentary system

abnormal palate bone morphology ( J:164801 )

• at P2

abnormal palatal shelf fusion at midline ( J:164801 )

• at P2

vision/eye

microphthalmia ( J:164801 )

• at E13.5