Phenotypes for Gt(ROSA)26Sor Tg(Krt1-15-cre/PGR*)22Cot MGI:6118191 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Krt1-15-cre/PGR*)22Cot/0
Genetic Background	involves: C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(HBEGF)Awai} mutation (4 available); any Gt(ROSA)26Sor mutation (1026 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:244536 )

• mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

cellular

increased cell proliferation ( J:244536 )

• mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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