Phenotypes Associated with This Genotype

Genotype
MGI:6140058

• Allelic Composition: Lrch1^em1Hwa/Lrch1^em1Hwa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular extravasation ( J:238772 )

• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice

hematopoietic system

abnormal cellular extravasation ( J:238772 )

• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice

immune system

immune system phenotype ( J:238772 )

N • populations of CD4+ cells in spleen and lymph nodes (LNs)

N • numbers of CD4+ T cells in spleen and draining LNs during induction of EAE with MOG same as in similarly treated wild-type mice

N • TCR usage in CD4+ T cells during induction of EAE with MOG same as in similarly treated wild-type mice

N • CD4+ T cell proliferation and Il2, Cd44 and Cd25 expression during induction of EAE with MOG same as in similarly treated wild-type mice

abnormal cellular extravasation ( J:238772 )

• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:238772 )

• MOG (35-55) peptide-induced EAE

• encephalitogenic CD4+ T cells from MOG-treated mice cause earlier disease onset with higher clinical scores when transplanted into sub-lethally irradiated WT recipient mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:238772