Phenotypes Associated with This Genotype

Genotype
MGI:6149720

hm1

• Allelic Composition: Usp15^L749R/Usp15^L749R
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:259382 )

• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit less death than wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

immune system

immune system phenotype ( J:259382 )

N • immune cells stimulated with phorbol ester PMA and ionomycin exhibit normal intracellular cytokine production and reactive oxygen species in neutrophils

abnormal T-helper 1 physiology ( J:259382 )

• L. monocytogenes-infected mice exhibit an increase in maturation and activation of CD4+ T cells in response to listeriolysin compared with wild-type cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )

• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit reduced body weight loss, lower clinical scores and less death with lower serum levels of cytokines (CCL3 and CCL4) than wild-type mice

decreased susceptibility to bacterial infection ( J:259382 )

• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit reduced body weight loss, lower clinical scores and less death with lower serum levels of cytokines (CCL3 and CCL4) than wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:259382 )

• in a non-microbial model of neuro-inflammation (EAE), mice treated with pertussis toxin exhibit less death than wild-type mice

decreased susceptibility to parasitic infection ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication with reduced leukocyte infiltration and MIP-1beta chemoattractant compared with wild-type mice

• bone marrow cells transferred into an irradiated recipient confers resistance to experimental cerebral malaria

• however, infected mice exhibit normal levels of IL-12p40, TNF, and IFNG

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

hematopoietic system

abnormal T-helper 1 physiology ( J:259382 )

• L. monocytogenes-infected mice exhibit an increase in maturation and activation of CD4+ T cells in response to listeriolysin compared with wild-type cells