Phenotypes Associated with This Genotype

Genotype
MGI:6150431

• Allelic Composition: Zfp106^{tm1b(KOMP)Wtsi}/Zfp106^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0033_4_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:241305 )

• in quadriceps muscles

• increased variation in fiber size

• very few centrally located nuclei

skeletal muscle fiber atrophy ( J:241305 )

• grouped atrophy in quadriceps muscles

• extensive, at 3 months of age

skeletal muscle fiber degeneration ( J:241305 )

• severe, at 3 months of age

behavior/neurological

abnormal physical strength ( J:241305 )

• reduced muscle strength from 4 weeks of age in all mice

decreased grip strength ( J:241305 )

nervous system

decreased motor neuron number ( J:241305 )

• significantly reduced number of choline-acetyltransferase-positive motor neurons in spinal cord

growth/size/body

cachexia ( J:241305 )

• due to muscle wasting

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis		DOID:332	OMIM:PS105400	J:241305