cardiovascular system
N |
• pulmonary artery and aorta in E16.5 embryos
|
• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae
• irregular spacing of right ventricular trabeculae
• disorganized left ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
|
• in E16.5 embryos
|
• in E16.5 embryos
• disorganized
• occupy much of lumen
• thicker trabecular zones
• thinner compact zones
|
• in E16.5 embryos
• free wall does not extend as close to heart apex of 8-months old mice as in control mice
• base closer to tricuspid valve than in controls
• base not aligned with base of left ventricle
• thicker trabecular zones
• thinner compact zones
• inconsistent size of trabeculae
• irregular spacing of trabeculae
|
• mean E/A ratio (flow velocity across mitral valve early in diastole divided by that late in diastole) in left ventricle of 2-months old mice is less than 1 in 8-months old mice, compared to greater than 1 in control mice
|
• in 8-months old mice
• lower acceleration of pulmonary artery (PA) flow, indicating reduced RV contraction force
• reduced fractional shortening
|
• lower acceleration of pulmonary artery (PA) flow in 8-months old mice
|
muscle
• irregular spacing of right ventricular trabeculae
• disorganized left ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae
|
• in E16.5 embryos
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
intrinsic cardiomyopathy | DOID:0060036 | J:228507 |