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Phenotypes Associated with This Genotype
Genotype
MGI:6150918
Allelic
Composition
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1tm1.1Tpy mutation (0 available); any Daam1 mutation (77 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• pulmonary artery and aorta in E16.5 embryos
• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae
• irregular spacing of right ventricular trabeculae
• disorganized left ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
• in E16.5 embryos
• disorganized
• occupy much of lumen
• thicker trabecular zones
• thinner compact zones
• in E16.5 embryos
• free wall does not extend as close to heart apex of 8-months old mice as in control mice
• base closer to tricuspid valve than in controls
• base not aligned with base of left ventricle
• thicker trabecular zones
• thinner compact zones
• inconsistent size of trabeculae
• irregular spacing of trabeculae
• mean E/A ratio (flow velocity across mitral valve early in diastole divided by that late in diastole) in left ventricle of 2-months old mice is less than 1 in 8-months old mice, compared to greater than 1 in control mice
• in 8-months old mice
• lower acceleration of pulmonary artery (PA) flow, indicating reduced RV contraction force
• reduced fractional shortening
• lower acceleration of pulmonary artery (PA) flow in 8-months old mice

muscle
• irregular spacing of right ventricular trabeculae
• disorganized left ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intrinsic cardiomyopathy DOID:0060036 J:228507


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory