Phenotypes Associated with This Genotype

Genotype
MGI:6150919

cn1

• Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy; Daam2^tm1Tpy/Daam2^tm1Tpy; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:228507 )

N • compact layer width in E17.5 embryos

abnormal myocardial fiber morphology ( J:228507 )

• in 2-months old mice

• disturbed A-band marker Actc1 striation pattern

• nearly absent intermediate filament Desmin striation

• shorter A-bands

• Z-bands faint or absent

• no apparent I-bands, H-bands or M-lines

• intersecting and disorganized thick fibers in severely affected areas

abnormal intercalated disk morphology ( J:228507 )

• lower-density material frequently observed between membranes of adjacent cardiomyocytes in 2-months old mice through electron microscopy

abnormal myocardial trabeculae morphology ( J:228507 )

• in E17.5 embryos

• failure of trabeculae to assimilate into compact zone, resulting in occluded ventricular lumens

• wider trabecular layers

• thicker individual trabeculae

• inter-trabecular spaces filled with detached endothelial cells

heart hypoplasia ( J:228507 )

• in 2-months old mice

abnormal heart left ventricle morphology ( J:228507 )

• in 2-months old mice

• thicker walls and septa

• smaller lumen

abnormal heart right ventricle morphology ( J:228507 )

• in 2-months old mice

• thicker walls and septa

• smaller lumen

decreased left ventricle systolic pressure ( J:228507 )

• in 2-months old mice

• lower ejection fraction

• reduced fractional shortening

decreased right ventricle systolic pressure ( J:228507 )

• in 2-months old mice

• acceleration of pulmonary artery (PA) flow

• reduced fractional shortening

abnormal myocardial fiber physiology ( J:228507 )

• increased cardiomyocyte proliferation

muscle

abnormal myocardial fiber morphology ( J:228507 )

• in 2-months old mice

• disturbed A-band marker Actc1 striation pattern

• nearly absent intermediate filament Desmin striation

• shorter A-bands

• Z-bands faint or absent

• no apparent I-bands, H-bands or M-lines

• intersecting and disorganized thick fibers in severely affected areas

abnormal intercalated disk morphology ( J:228507 )

• lower-density material frequently observed between membranes of adjacent cardiomyocytes in 2-months old mice through electron microscopy

abnormal myocardial trabeculae morphology ( J:228507 )

• in E17.5 embryos

• failure of trabeculae to assimilate into compact zone, resulting in occluded ventricular lumens

• wider trabecular layers

• thicker individual trabeculae

• inter-trabecular spaces filled with detached endothelial cells

abnormal A band morphology ( J:228507 )

• disturbed A-band marker Actc1 striation pattern and shorter A-bands in cardiomyocytes of 2-months old mice

abnormal H zone morphology ( J:228507 )

• no apparent H-bands in cardiomyocytes of 2-months old mice

absent M line ( J:228507 )

• no apparent M lines in cardiomyocytes of 2-months old mice

abnormal I band morphology ( J:228507 )

• no apparent I-bands in cardiomyocytes of 2-months old mice

absent Z line ( J:228507 )

• in cardiomyocytes of some 2-months old mice

diffuse Z line ( J:228507 )

• in cardiomyocytes of some 2-months old mice