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Phenotypes Associated with This Genotype
Genotype
MGI:6151127
hm1
Allelic
Composition		 Cd53tm1.1Nmg/Cd53tm1.1Nmg
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd53tm1.1Nmg mutation (0 available); any Cd53 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:260065 )
• B cells exhibit impaired PKC recruitment to the plasma membrane and phosphorylation of PKC substrates compared to in wild-type cells

hematopoietic system
abnormal B cell physiology ( J:260065 )
• B cells exhibit impaired PKC recruitment to the plasma membrane and phosphorylation of PKC substrates compared to in wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory