Phenotypes Associated with This Genotype

Genotype
MGI:6155766

• Allelic Composition: Cabp2^{tm1b(KOMP)Mbp}/Cabp2^{tm1b(KOMP)Mbp}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:255028 )

N • thresholds and amplitudes of distortion product otoacoustic emissions (DPOAEs)

N • morphology of inner hair cells and their afferent synapses

abnormal cochlear inner hair cell physiology ( J:255028 )

• increased inactivation of voltage-gated type 1.3 Ca2+ channels in mature IHCs of cochlear apical coil in vitro at age 5 weeks, using long (500 ms) step depolarizations or trains of brief (10 ms with 5 ms interval) depolarizations

abnormal hearing electrophysiology ( J:255028 )

• reduced firing rates and delayed and more variable spike timing of spinal ganglion neurons (SGNs) at sound onset

abnormal auditory brainstem response waveform shape ( J:255028 )

• reduced amplitude of response to 80 dB click stimuli at 20 Hz rate at age P49-P63

increased or absent threshold for auditory brainstem response ( J:255028 )

• increased in 6-24 kHz frequency range at age P49-P63

nervous system

abnormal cochlear inner hair cell physiology ( J:255028 )

• increased inactivation of voltage-gated type 1.3 Ca2+ channels in mature IHCs of cochlear apical coil in vitro at age 5 weeks, using long (500 ms) step depolarizations or trains of brief (10 ms with 5 ms interval) depolarizations

mortality/aging

mortality/aging ( J:255028 )

N • viable

reproductive system

reproductive system phenotype ( J:255028 )

N • fertile

vision/eye

vision/eye phenotype ( J:255028 )

N • intact retinal processing according to scotopic electroretinography (ERG) readings

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive nonsyndromic deafness 93		DOID:0110537	OMIM:614899	J:255028