Phenotypes Associated with This Genotype

Genotype
MGI:6157462

• Allelic Composition: Klhl3^tm2.1Esoh/Klhl3^tm2.1Esoh
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

salt-sensitive hypertension ( J:244278 )

• mice fed a high-salt diet for more than 3 days exhibit a higher delta systolic blood pressure than wild-type mice, indicating increased salt sensitivity

• however, mice fed a normal diet exhibit normal blood pressure

homeostasis/metabolism

acidemia ( J:244278 )

• mice show lower plasma pH

increased circulating potassium level ( J:244278 )

increased circulating chloride level ( J:244278 )

renal/urinary system

abnormal kidney morphology ( J:244278 )

• kidney shows decreased levels of WNK1 and WNK4

abnormal distal convoluted tubule morphology ( J:244278 )

• mice show hyperplasia of the distal convoluted tubules

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:244278