Analysis Tools
endocrine/exocrine glands
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• the tubules are vacuolated with inadequate tubule lumina development
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• the seminiferous epithelium is disorganized
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• the Sertoli cells are displaced from their normal position in homozygotes
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• leydig cells occupy relatively more of the testes in homozygotes than in age-matched wild-type controls
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immune system
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• homozygous mice reject sex-matched skin grafts from congenic BALB/cBy mice unlike wild-type mice
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reproductive system
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• by 3 weeks a delay in the onset of spermatogenesis is apparent and by 5 weeks greatly reduced numbers of spermatogenic cells are seen in homozygotes
• the spermatogenic cells that are present do not progress past the meiotic spermatocyte stages
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• the tubules are vacuolated with inadequate tubule lumina development
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• the seminiferous epithelium is disorganized
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• the Sertoli cells are displaced from their normal position in homozygotes
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• leydig cells occupy relatively more of the testes in homozygotes than in age-matched wild-type controls
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• males are completely sterile
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cellular
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• by 3 weeks a delay in the onset of spermatogenesis is apparent and by 5 weeks greatly reduced numbers of spermatogenic cells are seen in homozygotes
• the spermatogenic cells that are present do not progress past the meiotic spermatocyte stages
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