Phenotypes Associated with This Genotype

Genotype
MGI:6159891

• Allelic Composition: Slurp2^tm1.1Sgy/Slurp2^tm1.1Sgy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

abnormal epidermis stratum corneum morphology ( J:231067 )

• contains many tiny lipid droplets in volar surface of paws

hyperkeratosis ( J:231067 )

• on volar surface of paws

homeostasis/metabolism

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

adipose tissue

decreased total fat pad weight ( J:231067 )

decreased percent body fat/body weight ( J:231067 )

growth/size/body

slow postnatal weight gain ( J:231067 )

behavior/neurological

limb grasping ( J:231067 )

• clasping of hindlimbs in tail suspension test

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
palmoplantar keratosis		DOID:3390		J:231067