Phenotypes Associated with This Genotype

Genotype
MGI:6160731

• Allelic Composition: Insr^tm1Dac/Insr⁺; Ppp2r2a^igt10/Ppp2r2a⁺
• Genetic Background: involves: 129S4/SvJae * C3H/HeH * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:246319 )

• mice exhibit elevated plasma glucose levels from 18 weeks

increased circulating insulin level ( J:246319 )

• plasma insulin levels are elevated more than in either single heterozygote

impaired glucose tolerance ( J:246319 )

• mice show impaired glucose tolerance at 12 weeks of age

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

insulin resistance ( J:246319 )

renal/urinary system

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

behavior/neurological

polydipsia ( J:246319 )

• mice drink more and produce more urine as glycosuria develops

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:246319