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Phenotypes Associated with This Genotype
Genotype
MGI:6160754
Allelic
Composition		 Plp1tm1c(EUCOMM)Wtsi/Y
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Plp1tm1c(EUCOMM)Wtsi mutation (0 available); any Plp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:245100 )
N
• no APP+axonal spheroids, microgliosis, astrogliosis, or increase in T-lymphocytes are seen in the hippocampal fimbria at 26 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT hereditary spastic paraplegia 2 DOID:0110773 OMIM:312920
 J:245100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory