Phenotypes Associated with This Genotype

Genotype
MGI:6160757

• Allelic Composition: Plp1^{tm1c(EUCOMM)Wtsi}/Y; Cnp^tm1(cre)Kan/Cnp⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell number ( J:245100 )

♂ • density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age

microgliosis ( J:245100 )

♂ • microgliosis in the hippocampal fimbria at 26 weeks of age

immune system

increased T cell number ( J:245100 )

♂ • density of T-lymphocytes (CD3+ cells) in the fimbria is increased at 26 weeks of age

microgliosis ( J:245100 )

♂ • microgliosis in the hippocampal fimbria at 26 weeks of age

nervous system

microgliosis ( J:245100 )

♂ • microgliosis in the hippocampal fimbria at 26 weeks of age

abnormal hippocampal fimbria morphology ( J:245100 )

♂ • hippocampal fimbria exhibits APP+ axonal spheroids, microgliosis and astrogliosis, and increased density of T-lymphocytes

astrocytosis ( J:245100 )

♂ • moderate, but significant, astrogliosis in the hippocampal fimbria at 26 weeks of age

axonal spheroids ( J:245100 )

♂ • APP+ axonal spheroids are present in the hippocampal fimbria and corpus callosum at 26 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spastic paraplegia 2		DOID:0110773	OMIM:312920	J:245100