Analysis Tools
behavior/neurological
 |
• mice show reduced freezing responses upon exposure to the context which had been paired with aversive events earlier, indicating reduced fear response
• in short-term contextual tests following condition, mice show reduced fear response, indicating impaired memory acquisition
• -however, mice exhibit normal responses in the nociceptive test
|
|
|
• mice show reduced freezing responses upon exposure to auditory cues which had been paired with aversive events earlier, indicating reduced fear response
|
|
|
• in the Morris water maze, mice show a slower decline in latency and longer swimming trajectories to find the platform, indicating impaired spatial learning
• however, swimming speed is similar to wild-type controls
|
|
|
• mice exhibit elevated aggression in the resident-intruder paradigm, with the latency of the first attack to the intruder mouse shorter than in wild-type mice
• aggressive behavior is categorized as maladaptive since mice show little or no interest in social exploration prior to physical attacks and make shorter pauses between attack episodes
|
|
|
• in the elevated-plus maze, mice spend more time in the open arms of the maze and less time in the closed arms, indicating decreased anxiety levels
• however, no differences in time spent in the center are seen in the open field test
|
|
|
• in the activity chamber of the elevated-plus maze, mice show increased locomotor activity during the first 5 min but similar activity to wild-type in subsequent times, suggesting that reduced anxiety may manifest as hyperactivity during initial exposure to a novel environment which indicates disinhibition
|
|
|
• mice show little or no interest in social exploration prior to physical attacks on intruder mice
• in the three-chamber social approach test, mice spend a similar time exploring the stimulus mouse as an inanimate object compared to wild-type mice which spend more time exploring the stimulus mouse
• however, mice prefer the novel over familiar stimulus mouse in social memory tests indicating no sensory discrimination defect but rather reduced motivation for and/or interest in social interaction
|
growth/size/body
homeostasis/metabolism
|
|
• serum testosterone levels are elevated, although the difference is marginally non-significant
|
nervous system
|
|
• many dendritic spines of basolateral amygdala pyramidal neurons are thinner
|
|
|
• many dendritic spines of basolateral amygdala pyramidal neurons lack mature mushroom-like morphology
|
|
|
• basolateral amygdala pyramidal neurons show reduced spine density, approximately 45% of wild-type, from proximal to distal segments of dendritic branches
• pyramidal neurons in the motor complex show a slight, 9%, but significant, reduction in spine density
• however, no changes in dendritic arborization in the motor complex are seen
|
|
|
• basolateral amygdala pyramidal neurons show fewer dendritic intersections selectively in the concentric circles that are distant from the soma, indicating that extension and/or branching of dendrites are affected
• dendrites of basolateral amygdala pyramidal neurons show reduced total length
|
reproductive system
|
N |
• males are fertile
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| syndromic X-linked intellectual disability Claes-Jensen type | DOID:0060809 |
OMIM:300534 |
J:262206 | |
