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Phenotypes Associated with This Genotype
Genotype
MGI:6163991
cn8
Allelic
Composition		 Adamts9tm1.1Cvrk/Adamts9tm1.1Cvrk
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Mitf-cre)7114Gsb/0
Genetic
Background		 involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9tm1.1Cvrk mutation (0 available); any Adamts9 mutation (90 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (997 available)
Tg(Mitf-cre)7114Gsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased melanoblast apoptosis ( J:262498 )
• in some dTomato-positive tail melanoblasts at P0

embryo
increased melanoblast apoptosis ( J:262498 )
• in some dTomato-positive tail melanoblasts at P0
abnormal melanoblast morphology ( J:262498 )
• some dTomato-positive melanoblasts exhibit fragmentating indicating cell death unlike in control mice

nervous system
abnormal melanoblast morphology ( J:262498 )
• some dTomato-positive melanoblasts exhibit fragmentating indicating cell death unlike in control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory