Phenotypes Associated with This Genotype

Genotype
MGI:6164125

• Allelic Composition: Tafa3^em1Hssh/Tafa3^em1Hssh
• Genetic Background: C57BL/6NTac-Tafa3^em1Hssh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:257371 )

N • homozygotes show no significant differences in locomotor activity, fear learning and memory or object recognition memory relative to wild-type controls

increased anxiety-related response ( J:257371 )

♂ • in the elevated plus maze test, male (but not female) homozygotes spend significantly less time in the open arms than wild-type controls, indicating increased anxiety-like behavior

increased grooming behavior ( J:257371 )

• both male and female homozygotes spend a significantly longer time self-grooming than wild-type controls, indicating high spontaneous repetitive grooming behavior

increased stereotypic behavior ( J:257371 )

♂ • in the marble burying test, male (but not female) homozygotes bury significantly more marbles than wild-type controls, indicating increased repetitive (burying) behavior

abnormal social/conspecific interaction behavior ( J:257371 )

♂ • in the presence of female urine, male homozygotes make significantly fewer scent marks than wild-type and heterozygous males during a 5-min test session in the open field box, indicating impaired social communication

abnormal response to social novelty ( J:257371 )

• in the 3-chamber test, both male and female homozygotes show no preference for stranger 2 over stranger 1, whereas wild-type controls spend more time in the novel mouse chamber (stranger 2) than in the familiar mouse chamber (stranger 1)

• however, both male and female homozygotes spend significantly more time in the chamber with a stranger mouse than with a nonsocial novel object, indicating normal sociability

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:257371