Phenotypes Associated with This Genotype

Genotype
MGI:6188110

• Allelic Composition: Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2⁺
• Genetic Background: NZM2328.B6(Cg)-Ncf2^{tm1b(EUCOMM)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal redox activity ( J:260777 )

• NADPH oxidase activity is reduced but not absent

hematopoietic system

increased B cell number ( J:260777 )

increased germinal center B cell number ( J:260777 )

increased follicular B cell number ( J:260777 )

increased T cell number ( J:260777 )

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:260777 )

increased CD4-positive, alpha-beta memory T cell number ( J:260777 )

• increased numbers of activated memory T cells

increased CD8-positive, alpha-beta T cell number ( J:260777 )

increased activated T cell number ( J:260777 )

• increased numbers of activated memory T cells

abnormal spleen germinal center morphology ( J:260777 )

• spontaneous germinal center formation

homeostasis/metabolism

increased urine protein level ( J:260777 )

• proteinuria

• phenotype is more severe than in NZM2328 mice

immune system

increased B cell number ( J:260777 )

increased germinal center B cell number ( J:260777 )

increased follicular B cell number ( J:260777 )

increased T cell number ( J:260777 )

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:260777 )

increased CD4-positive, alpha-beta memory T cell number ( J:260777 )

• increased numbers of activated memory T cells

increased CD8-positive, alpha-beta T cell number ( J:260777 )

increased activated T cell number ( J:260777 )

• increased numbers of activated memory T cells

abnormal spleen germinal center morphology ( J:260777 )

• spontaneous germinal center formation

increased susceptibility to systemic lupus erythematosus ( J:260777 )

increased anti-double stranded DNA antibody level ( J:260777 )

mortality/aging

premature death ( J:260777 )

• mice do not survive beyond 10 months

renal/urinary system

increased urine protein level ( J:260777 )

• proteinuria

• phenotype is more severe than in NZM2328 mice

abnormal renal glomerulus morphology ( J:260777 )

• kidney disease is observed by 4 months of age, but is not as severe as in homozygote