Analysis Tools
behavior/neurological
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• in the T-maze left-right discrimination test, mice show reduced percentage of correct responses after directional reversal compared to controls, suggesting that mice exhibit increased persistence
• however, mice show normal memory in the T-maze forced-alternation test
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• mice spend less time in the light chamber for the light-dark transition test, in the open arms for the elevated plus-maze test, and in the center of the open-field indicating increased anxiety
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• mice show a lower acoustic startle response
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• mice show reduced number of social contacts in the social-interaction test but an increase in the duration per contact, resulting in an increase in total contact time
• however, the total duration of active contacts such as sniffing and following behavior is reduced
• mice show a reduction in contact time between familiar and stranger mice in the sociability and social-novelty preference test
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digestive/alimentary system
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• mice have shorter intestine
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• mice tend to show slower intestinal transit
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growth/size/body
megacephaly
(
J:235128
)
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• brain weight and volume are increased indicating macrocephaly
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nervous system
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• brain weight at E18.5 and in adulthood is increased
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• expression analysis indicates a delay in neurodevelopment in fetal stages
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• mice exhibit increased prepulse inhibition for 74- or 78-dB prepulses before a 120-dB startle stimulus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:235128 | ||
