Phenotypes Associated with This Genotype

Genotype
MGI:6192107

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:67389 )

• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days

• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

neoplasm

increased pancreas tumor incidence ( J:67389 )

• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days

• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:67389