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Phenotypes Associated with This Genotype
Genotype
MGI:6192107
Allelic
Composition		 Tg(Ela1-Tgfa)150Bri/0
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela1-Tgfa)150Bri mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreas tumor incidence ( J:67389 )
• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days
• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

neoplasm
increased pancreas tumor incidence ( J:67389 )
• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days
• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:67389

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory