Phenotypes Associated with This Genotype

Genotype
MGI:6192108

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:67389 )

• 100% of mice develop pancreatic tumors within 120 days after birth

increased pancreatic ductal adenocarcinoma incidence ( J:67389 )

• pancreatic carcinomas display a ductal phenotype, grow invasively into surrounding tissue, and metastasize

neoplasm

increased pancreas tumor incidence ( J:67389 )

• 100% of mice develop pancreatic tumors within 120 days after birth

increased pancreatic ductal adenocarcinoma incidence ( J:67389 )

• pancreatic carcinomas display a ductal phenotype, grow invasively into surrounding tissue, and metastasize

increased malignant tumor incidence ( J:67389 )

• pancreatic carcinomas metastasize to liver and lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:67389