Phenotypes Associated with This Genotype

Genotype
MGI:6192274

• Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm; Cd207^{tm2.1(cre)Bjec}/Cd207⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased dendritic cell number ( J:211690 )

• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver

• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers

immune system

increased dendritic cell number ( J:211690 )

• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver

• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers

liver inflammation ( J:211690 )

• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age

lung inflammation ( J:211690 )

• by 20 weeks of age, all mice show small lesions in the lung

liver/biliary system

liver inflammation ( J:211690 )

• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age

respiratory system

lung inflammation ( J:211690 )

• by 20 weeks of age, all mice show small lesions in the lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Langerhans-cell histiocytosis		DOID:2571	OMIM:246400 OMIM:604856	J:211690