Phenotypes Associated with This Genotype

Genotype
MGI:6192490

• Allelic Composition: Stat2^{tm1.1(STAT2)Diam}/Stat2^{tm1.1(STAT2)Diam}
• Genetic Background: C57BL/6-Stat2^{tm1.1(STAT2)Diam}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Flaviviridae infection ( J:261503 )

• infection with mouse-adapted Zika Virus (ZIKV-Dak-MA) results in increased susceptibility as compared to wild-type

• viral infection in pregnant dams results in trans-placental transmission and fetal infection although the does not spread to the brain in the mother

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:261503 )

• virus replicates, spreads to the brain and causes lethality in 3 week old mutant mice

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:261503 )

• virus replicates, spreads to the brain and causes lethality in 3 week old mutant mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Zika fever		DOID:0060478		J:261503