Phenotypes Associated with This Genotype

Genotype
MGI:6193619

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor⁺; Tg(Osr1-cre)4Mrt/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:234601 )

♂ • 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

♂ • tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

♂ • mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

♂ • 40.9% of mice exhibit mPIN lesions

♂ • mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

♂ • atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

♂ • foci of atypical cells partially fill the lumen of the ducts

♂ • mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:234601 )

♂ • mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

♂ • 40.9% of mice exhibit mPIN lesions

♂ • mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

♂ • atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

♂ • foci of atypical cells partially fill the lumen of the ducts

♂ • mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

increased malignant tumor incidence ( J:234601 )

♂ • malignancy, with vascular invasion by neoplastic cells or local invasion of the tumor beyond the basement membrane into surrounding stromal tissues is seen in some mice

increased prostate gland adenocarcinoma incidence ( J:234601 )

♂ • 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

♂ • tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

reproductive system

increased prostate gland adenocarcinoma incidence ( J:234601 )

♂ • 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

♂ • tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

♂ • mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

♂ • 40.9% of mice exhibit mPIN lesions

♂ • mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

♂ • atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

♂ • foci of atypical cells partially fill the lumen of the ducts

♂ • mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:234601