Phenotypes Associated with This Genotype

Genotype
MGI:6193916

• Allelic Composition: Tg(Myh6-Prkaca)33Eno/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:263774 )

• mice display higher mortality, with mice dying starting after 5 weeks of age and showing about 70% survival at 30 weeks of age

cardiovascular system

increased myocardial fiber size ( J:263774 )

• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged

enlarged heart ( J:263774 )

• mice develop enlarged hearts by 13 weeks of age

cardiac hypertrophy ( J:263774 )

• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated

thick ventricular wall ( J:263774 )

• ventricular walls are only moderately thicker at 10 weeks of age

cardiac fibrosis ( J:263774 )

• dilated hearts show mild fibrosis

dilated cardiomyopathy ( J:263774 )

• mice develop dilated cardiomyopathy by 13 weeks of age

• however, hearts are normal at 4-8 weeks of age

congestive heart failure ( J:263774 )

• mice exhibit symptoms indicative of congestive heart failure

homeostasis/metabolism

abnormal atrial thrombosis ( J:263774 )

• atria frequently contain organized thrombi

edema ( J:263774 )

• in severe cases, mice develop edema

muscle

increased myocardial fiber size ( J:263774 )

• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged

dilated cardiomyopathy ( J:263774 )

• mice develop dilated cardiomyopathy by 13 weeks of age

• however, hearts are normal at 4-8 weeks of age

growth/size/body

enlarged heart ( J:263774 )

• mice develop enlarged hearts by 13 weeks of age

cardiac hypertrophy ( J:263774 )

• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:263774