Phenotypes Associated with This Genotype

Genotype
MGI:6195746

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:263520 )

• mice start to die from 5 months of age onwards, with 53% of mice dying by 15 months

neoplasm

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

increased T cell acute lymphoblastic leukemia incidence ( J:263520 )

• mice exhibit precursor T-cell lymphoblastic leukemia (CD45/CLA+; CD3+; CD45/B220- and IBA-1- with presence of cKit+ cells)

• the pre T-cell lymphoblastic leukemia likely originates from the thymus with sheets of medium to large-size lymphoid cells infiltrating into surrounding tissues, including lung, heart, and cranial mediastinum and systematically into lymph nodes, liver, spleen, kidney and bone marrow

endocrine/exocrine glands

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

immune system

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

hematopoietic system

increased thymus tumor incidence ( J:263520 )

• mice develop thymus tumors from 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell adult acute lymphocytic leukemia		DOID:5602		J:263520