Phenotypes Associated with This Genotype

Genotype
MGI:6195751

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:263520 )

• mice exhibit about 50% survival at 8-10 months of age

neoplasm

increased T cell acute lymphoblastic leukemia incidence ( J:263520 )

• mice develop T-cell lymphoblastic leukemia, with dense neoplastic infiltrates in the cranial mediastinum characterized by medium to large-sized atypical lymphoid cells with numerous mitotic figures and dissemination to the heart

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell adult acute lymphocytic leukemia		DOID:5602		J:263520