Phenotypes Associated with This Genotype

Genotype
MGI:6196044

• Allelic Composition: Tg(CAG-Alk*F1174L,-luc)60Jhsc/0; Tg(Dbh-icre)1Gsc/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:186696 )

• extensive liver metastases is seen in some mice

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression

endocrine/exocrine glands

adrenal gland hyperplasia ( J:186696 )

• some adrenals appear hypertrophic in mice that do not develop tumors

nervous system

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:186696